Endocrine Abstracts

Negative caloric balance and low body weight can impair pituitary function. This syndrome is well recognised in women, but it is less often diagnosed or considered in men. We present the case of a 16-year-old male who presented with increasing tiredness, bloating and inability to focus over a period of 3 months. He had been involved in regular sporting activities over last few years recently increased the physical activity focusing on fitness with a calorie deficit diet leadin...

Adrenal cortical carcinoma (ACC) is extremely rare, the incidence is 0.5 - 2 cases per million populations per year. Most ACCs occur as sporadic tumours. It is more common in females and can occur at any age with a peak in fifth and sixth decades of life. We present a 45-year-old otherwise well and fit lady presented with headache, lethargy, and two stone rapid weight gain over a period of 6 months. She also had associated nocturia, insomnia, night sweats, hirsutism, and acne....

Total thyroidectomy is one of the definitive treatments for Graves’ disease. This case describes the rare recurrence of thyroid eye disease (TED) and thyrotoxicosis due to thyroid remnant tissue. We present a 58 year old lady with Graves’ disease first seen in 2005 with positive TSH receptor antibodies (TSHRab) level of 2.5 U/l. She had a large multinodular goiter at presentation and this continued to grow with retrosternal extension and subsequent tracheal deviation...

Cushing’s syndrome can lead to various complications, including pathological fracture. As an initial presenting symptom pathological fracture is not very common in Cushing’s syndrome. This abstract aims to present a case study of a female patient with multiple pathological fractures at a young age and subsequently diagnosed with Cushing’s syndrome. A 32-year-old female (at the time of referral) after a stress fracture of the right neck of the femur without any t...

Ectopic Cushing's syndrome is rare, accounting for 5–10% of all cases of Cushing's. The majority are casued by small cell lung cancer and neuroendocrine tumours.We report a case of a 59 year old male who presented with osmotic symptoms after newly diagnosed diabetes, hypokalaemia and metabolic alkalosis with clinical features suggestive of Cushing's. Initial random cortisol was >2000 nmol/l and 24 hour urin...

Ectopic Cushing's syndrome is rare, accounting for 5–10% of all cases of Cushing's. The majority are casued by small cell lung cancer and neuroendocrine tumours.We report a case of a 59 year old male who presented with osmotic symptoms after newly diagnosed diabetes, hypokalaemia and metabolic alkalosis with clinical features suggestive of Cushing's. Initial random cortisol was >2000 nmol/l and 24 hour urin...

A 74 year-old woman had 4 presentations to the hospital with severe symptomatic hypercalcemia despite intensive medical therapy. She had a background of right hemithyroidectomy, hypothyroidism and rheumatoid arthritis. She first presented with symptoms of muscle weakness, vomiting, confusion and muscle aches. Her initial test results showed an adjusted calcium level of 3.79 mmol/l and PTH of 28.1 pmol/l; she was treated with IV fluids, Pamidronate 60 mg and discharged home wit...

Functional hypothalamic amenorrhoea (FHA) is a disorder associated with functional inhibition of the hypothalamic-pituitary-ovarian axis due to deficiency of pulsatile GnRH. The incidence of FHA ranges from 15 to 48% of all secondary amenorrheas. The abnormal GnRH secretion leads to decreased pulses of gonadotropins, absent midcycle surges in luteinizing hormone (LH) secretion, absence of normal follicular development, anovulation, and low estradiol (E2). Causes of FHA can be ...

Various haematological abnormalities have been reported to be associated with treatment of hyperthyroidism. The Association between neutropenia and untreated hyperthyroidism has been described although the aetiology is unknown, but thought to be related to autoimmunity.Case: A 41 year old Nepalese lady presented with a three month history of poor sleep and loss of weight. She was found to be thyrotocxic with T4 of 64 mol/l (10–24), T...

Graves’ disease is one of the reversible causes of pulmonary hypertension (PAH). The association was first reported in 1980. Studies have suggested an elevated pulmonary artery systolic pressure in about 36% of patients with Graves’ disease by Doppler echocardiography. We report a case of Graves disease associated with pulmonary hypertension in a young female.Case report: A 41 year old female presented with history of worsening breathless and p...